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KMID : 0387420060170010037
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Korean Society of Oriental Neuropsychiatry
2006 Volume.17 No. 1 p.37 ~ p.57
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The Effects of ChongMyungTang(CMT) and ChongMyungTang added Hibiscus syriacus(MCMT) Extract on the Alzheimer’s Disease Model Induced by CT-105 and ${\beta}A$
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Park Ji-Un
Jung In-Chul
Lee Sang-Ryong
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Abstract
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Objective: This research investigates the effect of the CMT and MCMT on Alzheimer‘s disease.
Methods: The effects of the CMT and MCMT extract on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, GFAP, CD68 abd CD11b; (5) the infarction area of the hippocampus in Alzheimer’s diseased mice induced with ${\beta}A$ were investigated.
Results:1. The CMT and MCMT extract suppressed the expression of APP, AChE, and mRNA in PC-12 cells treated with CT-105. 2. The CMT and MCMT extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and MCMT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer’s disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The CMT and MCMT extract suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, GFAP, CD68 abd CD11bCD68/GFAP, in the mice with Alzheimer’s disease induced by ${\beta}A$. 5. The CMT and MCMT extract reduced the infarction area of hippocampus with Alzheimer’s disease induced by ${\beta}A$ 6. The MCMT showed more excellent effects than CMT in the every experiments except PC-12 cells.
Conclusion: These results suggest that the CMT and MCMT extract may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the CMT and MCMT extract for Alzheimer’s disease is suggested for future research.
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KEYWORD
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ChongMyungTang(CMT), ChongMyungTang added Hibiscus syriacus(MCMT), Alzheimer’s Disease
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